Health and Fitness

Genetic threat rating has potential to enhance prevention of extreme knee and hip osteoarthritis

A analysis workforce has developed a threat rating based mostly on people’ genetic information to foretell their probability of needing hip or knee substitute surgical procedure for osteoarthritis. The rating’s predictive skill was validated in a examine revealed in Arthritis & Rheumatology.

The rating incorporates 10 genetic sequence variants for predicting an individual’s threat of needing knee substitute surgical procedure and 37 genetic sequence variants for predicting the danger of needing hip substitute surgical procedure.

Among 12,093 people of European genetic descent aged ≥70 years, 1,422 (11.8%) had knee replacements and 1,297 (10.7%) had hip replacements. Participants with excessive threat scores had a 1.44-times increased odds of knee substitute and a 1.88-times increased odds of hip substitute, in contrast with these with low threat scores.

“Genetic scores, such as the one we developed, do not change over a person’s life. They provide an individual with further information about their risk of severe osteoarthritis in later life and have the potential to improve prevention of severe knee and hip osteoarthritis by identifying those who may benefit from early intervention,” stated senior creator Flavia Cicuttini, PhD, of Monash University, in Australia.


Journal reference:

Lacaze, P., et al. (2022) Genomic threat rating for superior osteoarthritis in older adults. Arthritis & Rheumatology.

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