Parthenogenesis: Fatherless mouse pups develop from unfertilised eggs with gene editing

Parthenogenesis, the event of offspring from unfertilised eggs, was considered unattainable in mammals, however researchers have used genetic trickery to make it occur


7 March 2022

The parthenogenetic mouse and the offspring. The parthenogenetic mouse was generated by targeted epigenetic rewriting of multiple imprinting control regions. The parthenogenetic mouse exhibited normal reproductive performance as an adult.

An grownup mouse that developed from an unfertilised egg, and her pups


A genetically manipulated mouse pup born from an unfertilised egg survived to maturity and reproduced, demonstrating a kind of replica that was considered unattainable in mammals.

In many crops and a few animals, offspring can develop from unfertilised eggs or ovules in a course of known as parthenogenesis.

In regular sexual replica in animals, an egg and a sperm – every containing one set of genetic materials – fuse, giving the embryo two copies of every gene. To keep away from conflicts …

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